B.Tech in Biotechnology

DURATION: 4 Years
ELIGIBILITY: The eligibility for B.Tech. Biotechnology is class XII with PCB/ PCM / PCMB (Min 50 %) ….know more

Introduction:

B. Tech. Biotechnology is a four-year undergraduate program. Biotechnology is the branch of science which involves amalgamation of biotic systems with Technology in order to improve production and create value addition to industrially significant products such as pharmaceuticals, crops, food and dairy etc. Biotechnology offers jobs to the undergraduate students in multifarious domains. Program is offering specializations in:

i) Computational Biology: Computational Biology is a field of biological study concerned with solving complex biology and medical issues/problems through computational and mathematical methods. It is a trending course for those with dual interest in biological sciences, vaccine technology, and computer science, Machine Learning, Artificial Intelligence and Big Data Analysis.

ii) Industrial Biotechnology: Industrial biotechnology is a rapidly growing field that offers far-reaching benefits at both the national and international level. This specialization enables students to develop future-ready skills by equipping them with hands-on-approach along with theoretical knowledge that will improve their employability quotient.

Program Highlights:

  • Industry oriented curriculum.
  • MoU with various renowned industries like Biocon, Bikano, Rapture Biotech, Codon Biotech etc. for certification and internship.
  • Practical knowledge through state of the art laboratories equipped with high end instruments and industrial exposure.
  • Strong interdisciplinary research base with government funded projects from SERB, AKTU, and UPCST.
  • Skill development of students by conducting value addition programs and various hands-on workshops from renowned organizations.
  • International exposure to students.
  • Personalized mentoring, Career counseling and Personality Development by Faculty members, industry stalwarts and Alumni.
  • Excellent Track record of Placements with Top Ranked companies like Biocon, Nestle, Mankind Pharma, Coca-Cola, PepsiCo, Lal Path labs, Intas Pharmaceuticals, Bikano, Dabur, Cadbury, Core Diagnostics and Apollo.

Eligibility:

B. Tech. Biotechnology

The eligibility for B. Tech. Biotechnology is class XII with PCB/ PCM / PCMB (Min 50 %).

Lateral Entry

Candidates who have passed the qualifying examination securing minimum 50% (45% for SC/ST/ Reserve candidates) marks in aggregate without any grace marks.

Department of Biotechnology Research Labs:

Biotechnology is the use of living systems and organisms to develop products. It deals with the study of microorganisms – MICROBIOLOGY; study of living cells, biomolecules and their metabolism- BIOCHEMISTRY; study of various techniques like microscopy, electrophoresis, chromatography, etc – ANALYTICAL TECHNIQUES; study of genomes & proteomes GENETICS & MOLECULAR BIOLOGY; study of body defence mechanism, immunity& disease – IMMUNOLOGY; study of drugs and computational tools – BIOINFORMATICS.

1. MICROBIOLOGY and FERMENTATION LAB – Microbiology is the study of microorganisms such as bacteria, viruses, fungi, etc. Microbiology labs include the study of these microorganisms – their growth, isolation, and culturing. Microbiology Labs include the study of organisms at the cellular level along with their roles in the development of biological products. Lab Instruments used are microscopes, colony counter, Laminar Air Flow etc. Fermentation is a metabolic process that converts sugar to acids, gases, or alcohol. It occurs in yeast and bacteria, and also in oxygen-starved muscle cells, as in the case of lactic acid fermentation. Fermentation Labs includes study of production of various enzymes and products using microorganisms. Instruments include Fermentor, Incubator shaker, etc.

Key Modules: Preparation – nutrient agar slants, plates, nutrient broth ; Sterilization; Inoculation of agar slants, agar plate and nutrient broth ;Culture of microorganisms; Identification &Staining of cells; Isolation of microbes and Colony counting; Microscopy
Fermentative production of Penicillin, ethanol, citric acid, industrial enzymes using specific microbial strains under submerged fermentation conditions; study the induction effect of β-galactosidase enzyme in E.coli.; Computational Design of Fermentative Process; solid-state fermentation for production of biopolymers & surfactants.

2. PLANT TISSUE CULTURE LAB – It includes a collection of techniques used to maintain, grow as well as clone plant cells, tissues or organs under sterile conditions on a nutrient culture medium of known composition.

Key Modules: Sterilization techniques; Preparation of Stocks solution and Plant Tissue Culture Media; Explant selection, treatment, and inoculation; Subculture of initiated cultures; Acclimatization of cultures; Extraction of proteins from plants and its estimation; Extraction of DNA/RNA from plants and its estimation, etc.

3. GENETICS & MOLECULAR BIOLOGY LAB – It deals with the study related to genetic material including DNA, RNA, and proteins. Lab involves extraction, isolation, and amplification of DNA. Lab Instruments used are PCR, electrophoresis unit, chromatographic unit, etc.

Key Modules: Estimation of DNA & RNA content; Determination of Tm of DNA & RNA; Isolation of Plasmid DNA, bacterial/fungal genomic DNA, plant DNA; Purification of DNA; Polyacrylamide gel electrophoresis of DNA; PCR amplification of DNA.

4. IMMUNOLOGY LAB – It is the study of all aspects of the immune system including its structure and function, disorders of the immune system, blood banking, immunization, and organ transplantation. Instruments include PCR machine, ELISA reader, Centrifuge, etc. Key Modules: Determining blood group & Rh factor of blood; Single, radial & double immunodiffusion; Rocketimmunoelectrophoresis & counter current immunoelectrophoresis; ELISA – Sandwich, Indirect, Competitive; Identification of blood cells; Perform differential count of samples, etc.

5. BIOCHEMISTRY LAB – Biochemistry is the science that deals with various biochemical processes, biomolecules, and the metabolism in living organisms. Biochemistry lab brings together biology and chemistry where techniques are used to study these biomolecules. Lab Instruments used are spectrophotometer, colorimeter, pH meter, chromatographic unit, electrophoresis unit, etc.

Key Modules: Preparation of solutions, buffers, emulsions; pH meter standardization; Spectroscopy; Titration; Estimation of biomolecules – carbohydrates, proteins, fatty acids, nucleic acids; Electrophoresis, Chromatography, etc. 2.) IMMUNOLOGY LAB – It is the study of all aspects of the immune system including its structure and function, disorders of the immune system, blood banking, immunization, and organ transplantation. Instruments include PCR machine, ELISA reader, Centrifuge, etc. Key Modules: Determining blood group & Rh factor of blood; Single, radial & double immunodiffusion; Rocketimmunoelectrophoresis& counter current immunoelectrophoresis; ELISA – Sandwich, Indirect, Competitive; Identification of blood cells; Perform differential count of samples, etc.

6. BIOINFORMATICS LAB – It basically deals with the computational study of biological information. Its study includes the study of databases & tools and their application. Lab includes use of computer systems along with softwares, online databases and tools. Key Modules: Alignment – DNA & Protein (BLAST, FASTA, CLUSTALW, etc.); Genome Annotation & Identification of Genes, ORF and Exons; Protein Stricture Prediction – secondary & tertiary; Visualize tertiary structure of proteinS; Phylogenetics; Primer Design;2D QSAR; Perl

7. PROJECT LAB – Research Projects at both B.Tech. & M.Tech. level are held in Project Laboratories. Major Lab Instruments include the Environmental chamber, Refrigerated Centrifuge, Memmert type incubator shaker, Ultradeep Refrigerator, etc.

Research:

Government Funded Research Projects of Faculty:
Name of the faculty Project title Project Type Research/ Consultancy Funding Agency Amount Duration
Mr. Vikas Chandra Gupta (PI) & Dr Meenu Singh (Co-PI) Lignocellulosic fermentable sugar concentration enrichment using optimized membrane model system Research CRIP funding through TEQIP III of AKTU 3,00,000 12 MONTHS (2019-20)
Dr Abhinav Kumar An investigation on the identification of microRNAs and differential display analysis of gene expression in leaf curl disease affected Papaya plants, Research Science and Engineering Research Board, Govt of India 30,77,667 3 YEARS (2016-19)
Dr Abhinav Kumar Development and Use of DNA-Based Viral Gene Silencing Vector using modified satellite molecule associated with Cotton leaf curl virus Research Visvesvaraya Research Promotion Scheme (VRPS), APJAKTU 4,99,600 2 YEARS (2019-21)
Dr. Garima Gupta Optimization of coagulation process using a combination of Moringa oleifera leaves with aluminium sulphate in water treatment. Research CRIP funding through TEQIP III of AKTU 3,00,000 12 MONTHS (2019-20)
Dr Arpita Mishra Isolation and Cloning of WRKY Transcription factor involved involved in response to salt and drought stress Research Visvesvaraya Research Promotion Scheme (VRPS), APJAKTU 5,00,000 2 YEARS (2017-19)

Research:

Government Funded Research Projects of Students:
Name of the student Name of the faculty Project title Project Type Research/ Consultancy Funding Agency Amount Duration
Mr. Vikas Chandra Gupta & Dr Meenu Singh Development of economically viable biofuel solution of Delhi-NCR Stubble (rice straw) burning issues Research CST-UP 20,000 6 MONTHS (2019-20)
Mr. Vikas Chandra Gupta & Dr Meenu Singh Design and development of membrane system for fermentable sugar concentration enrichment from pre-treated rice straw hydrolysate Research CST-UP 20,000 6 MONTHS (2018-19)
Mr. Vikas Chandra Gupta & Dr Meenu Singh Development of commercial hydroponics set up for industrial effluent treatment using an economical plant with phytoremediation property Research CST-UP 20,000 6 MONTHS (2018-19)

Faculty Publications:

JOURNALS

1. K. Rhaeva, & A. Kumar, “Application of virus-induced gene silencing in crops: mechanism, assessment of risk factors and ecological advantages In Geminivirus: Detection, Diagnosis and Management”, Academic Press, pp. 589-597, 2022.
2. Varma A, Gupta G, Department of Biotechnology, College of Engineering and Technology IILM, Greater Noida, U.P., India, Optimization of Starch-Based Biofilm Formulation and Biodegradability Assessment, J. Pharm. Sci. & Res. Vol. 14(2), 2022, 705-708
3. S. Desai, P. Sharma, P. Kashyap, B. Choudhary, J. Kaur. 2022. “Bioactive compounds, bio-functional properties and food applications of Garcinia indica: A Review” Journal of Food Biochemistry. 2022; 00: e14344.
4. P. Yadav and V. C. Gupta, “Comparative study on biosorption of arsenite ions onto raw and chemically activated orange peel powder in batch reactor,” International Journal of Engineering, Science and Technology, vol. 13, no. 1, pp. 158–170, Jul. 2021.
5. R. Chandra, “In Silico Study of Secondary Structure of Hemoglobin Protein”, RJPT,14(12),2021.
6. R. Chandra, S. Saha, T. Majumder, “A serological study of Dengue Virus and Chikungunya virus: To check the infection and co-infection between these two viruses in Tripura”, IJPR,13(4),2021.
7. R. Chandra, “Molecular Docking studies of Drug receptor Interaction for Bioweapon Brucella” in AICTE Sponsored Online National Conference on “Precision Medicine: Current Scenario and Future Aspects” organized by NIT Silchar, Assam, October 2021.
8. R. Chandra, “In Silico Analysis and Molecular Docking Studies of Cajanus cajan Lectin against Aminopeptidase-N Receptor from Acyrthosiphonpisum” in (27th International Conference of International Academy of Physical Sciences (CONIAPS XXVII) on “Mathematical Modelling in Biological Sciences” organized by NIT Silchar, Assam, October 2021.
9. P. Singh et al, “Computational Drug Repurposing for the Development of Drugs Against Coronaviruses”, In Silico Modeling of Drugs Against Coronaviruses, Springer Nature, (pp. 135-162), Apr 2021.
10. H. Faiz, and A. Kumar, “Development of immunity against cotton leaf curl virus using antisense ac4 gene.” Research Journal of Biotechnology vol. 16, pp. 9, 2021.
11. A. Kumar, N. Kashyap, & R. Gupta, “Association of a monopartite chilli leaf curl virus and defective betasatellite molecule isolated from leaf curl disease affected papaya in India”. The Journal of Horticultural Science and Biotechnology, Vol. 96(4), pp. 538-543, 2021.
12. D. Singh, V. Sinha, A. Kumar, and S. Teotia, “Small RNAs and cold stress tolerance in Plant Small RNA”, Academic Press, pp. 209-230, 2020.
13. V. Sinha, and A. Kumar, “Methods of Seed Enhancement. Advances in Seed Production and Management”, pp. 489-501, 2020.
14. Garima Gupta, College of Engineering and Technology IILM, Greater Noida, U.P., India, Synergistic Effect of Antioxidant Property of Aloe Vera Leaf Skin and Mango Seed Kernel Extract on Shelf Life of Various Edible Oils, Journal of Pharmaceutical Sciences and Research (JPSR) ISSN: 0975-1459 Volume 12(7), 2020, 910-913
15. A. Kumar, J. Ahmad, & J. A. Khan, “Engineering resistance against cotton leaf curl disease with the application of antisense technology” Research Reports, vol. 4, 2020.
16. P. Singh, & R. K. Singh, “Synthesis of Hydrazone Derivatives and In-silico docking studies against JNK protein to assess anticonvulsant activity of synthesized derivatives” Journal of Pharmaceutical Sciences and Research, vol.12(6), pp. 770-779, 2020.
17. P. Singh, and D. Verma, “APPLICATION OF SYSTEMS BIOLOGY APPROACH FOR INVESTIGATION OF PAN GENOME AND PHYLOGENETICS IN VARIOUS STRAINS OF ANAPLASMA PHAGOCYTOPHILUM” Journal of microbiology, biotechnology and food sciences, vol. 10(3), pp. 445-448, 2020.
18. R. J. Khan, R. K. Jha, G. M. Amera, J. Muthukumaran, Singh A. K, Singh R. P . “A Comprehensive in silico Study Towards Understanding the Inhibitory Mechanism of Lactoperoxidase by Dapsone and Propofol”. Science and Current Computer- Aided Drug Design, Vol-17, issue-4, Pages-550-559, Jun 2020.
19. Singh et al, “A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods” Journal of Genetic Engineering and Biotechnology, Volume 18, issue-1, Page 1-12, Nov 2020.
20. V. C. Gupta, M. Singh, and S. Prasad, “Comparative Fermentable Sugar Yield from Pretreated Rice Straw by Trichoderma reseei and Aspergillus tamarii Using Plackett–Burman Method,” Biosc.Biotech.Res.Comm, vol. 12, no. 4, 2019.
21. V. C. Gupta, M. Singh, M. Chugh, R. Marwah, and R. Hashmi, “Preliminary Studies of Vegetable Plants Growth Index Under Controlled Condition of Soilless System,” Trends Biosci, vol. 11, no. 24, pp. 3268–3273, 2018.
22. V. C. Gupta, M. Singh, and S. Prasad, “Comparative Fermentable Sugar Yield from Pretreated Rice Straw by Trichoderma reseei and Aspergillus tamarii Using Plackett–Burman Method,” Biosc.Biotech.Res.Comm, vol. 12, no. 4, 2019.
23. Garima Gupta, Sumit Kumar, Shri Venkateshwara University, Gajraula, Amroha, U.P., India, Optimizing extraction method for the study of synergistic effect on antioxidant property in aloe vera leaf skin and mango seed kernel extract, European Journal of Biomedical and Pharmaceutical Sciences (EJBPS), ISSN 2349-8870, Volume 6, Issue 13, 2019, 488-493
24. Garima Gupta, Sumit Kumar, Shri Venkateshwara University, Gajraula, Amroha, U.P., India, Comparative Antioxidant properties analysis of byproducts of selected fruits, European Journal of Biomedical and Pharmaceutical Sciences (EJBPS), ISSN 2349-8870, Volume 6, Issue 13, 2019, 402-405
25. R. Chandra, S. Kumar, “Pairwise sequence alignment – A global alignment approach”, EJPMR, 6(2):270-272, 2019.
26. R. Chandra, “Study of Microarray biological data using data mining”, WJPPS,8(1):1443-1452,2019.
27. N. Srivastava, “Production of food-processing enzymes from recombinant microorganisms. In Enzymes in food biotechnology”, Academic Press, pp. 739-767, 2019.
28. N. Srivastava and M. Kuddus, “ Use of ion-exchange resin in reactive separation” Applications of Ion Exchange Materials in Chemical and Food Industries, pp. 125-137, 2019.
29. R. Chandra, S. Kumar, M. Khan, “Study of miRNA-based gene regulation involved in squamous lung carcinoma by assistance of argonaute protein”, IJRDPL,7(1):2913-2917,2018.
30. P. Singh, N. Tanwar, T. Saha, A. Gupta, & S. Verma,. Phytochemical screening and analysis of Carica papaya, Agave americana and Piper nigrum. Int. J. Curr. Microbiol. App. Sci, 7(2), 1786-1794, 2018.

BOOK CHAPTERS

1. S. Prasad, V. C. Gupta, R. Bhatt, and M. S. Dhanya, “Ethanol Production from Sugarcane: An Overview,” Input Use Efficiency for Food and Environmental Security, pp. 665–686, 2022.
2. C. Sosalagere, B. Kehinde, B. Choudhary, P. Sharma. “Bioactive peptides production using microbial sources”. Microbial resource technologies for sustainable development. pp. 299-314,2022.
3. Garima Gupta, “Biocomposites in Food Packaging”, Polymeric Biomaterials: Fabrication, Properties and Applications, CRC Press.
4. Srishti, S. S. Narayan, V. C. Gupta R. K. Basniwal, A. Singh, “Green Synthesis of Carbon-Based Nanomaterials: Industrial Applications,” in Encyclopedia of Green Materials, vol. 1, Springer, Singapore, pp. 1–12, 2022.
5. S. Pandey, S. Pandey, A. Alam, “Isolation and characterization of endophytic bacteria associated with gametophytes of bryophytes in Mount Abu (Rajasthan)”, Rhizosphere, vol. 24, 100592, Dec 2022.
6. S. Pandey, “Biotechnological studies of medicinal plants to enhance secondary metabolites under various environmental pollution,” in: Environmental Pollution and Medicinal Plants, 1st ed., A. Husen, Ed, Boca Raton: CRC Press, Taylor & Francis Group, pp.177-192, 20.
7. S. Pandey, A. Husen, “Role of plant stem or shoot cutting positions and hormone treatments in adventitious root formation,” in: Environmental, Physiological and Chemical Controls of Adventitious Rooting in Cuttings, 1st ed., A. Husen, Ed, Academic Press, Elsevier, 2022, pp. 367-375.
8. S. Sandhya, S. Mehta S, S. Pandey, A. Husen, “Adventitious root formation in cuttings as influenced by genotypes, leaf area, and types of cuttings,” in: Environmental, Physiological and Chemical Controls of Adventitious Rooting in Cuttings, 1st ed., A. Husen, Ed, Academic Press, Elsevier, 2022, pp. 381-390.
9. Singh et al, “Ligand-Based Approaches for the Development of Drugs Against SARS- CoV-2”, In Silico Modeling of Drugs Against Coronaviruses, Springer Nature, (pp. 117-134), Apr 2021.
10. Singh et al, “Computational Drug Repurposing for the Development of Drugs Against Coronaviruses”, In Silico Modeling of Drugs Against Coronaviruses, Springer Nature, (pp. 135-162), Apr 2021.
11. V. C. Gupta, M. Singh, S. Prasad, and B. N. Mishra, “Sustainable and Economical Approaches in Utilizing Agricultural Solid Waste for Bioethanol Production, Handbook of Solid Waste Management: Sustainability through Circular Economy,(pp.1-29),2020.

PATENTS

1. V. C. Gupta, M. Singh, S. Prasad, and Singh P., “Media and system for soilless phytoremediation by Sorghum bicolorplant ,”202211002268 , Jan 2022.
2. A. Singh, A. Rai, G. Kumar, R. Tiwari, S. Asthana, P. Bhargava, B. Choudhary, D. Tripathi, A. Gupta and S. Shukla., “Eco friendly slow release urea fertilizer based on starch-G-poly composite with natural char nanoparticles” Australian patent # 2121104070 (Granted on 23/03/22).

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