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Dr. Rashmi Prabha Singh
Assistant Professor

Dr. Rashmi Prabha Singh has received her full time Ph.D. degree on “Structural and Functional Studies of Mammalian Heme Peroxidases” from the Department of Biophysics, All India Institute of Medical Sciences (AIIMS) New Delhi. She has completed her M.Sc. in Industrial Biotechnology from C. C. S. University Meerut, Campus. She was the topper of her M. Sc. Batch. She has done her M.Sc. Research Project on “In vitro studies in Mentha piperita & learning some basic Techniques of Molecular Biology” in Plant Tissue Culture Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow.
She has qualified CSIR-NET-JRF (2007) and CSIR-NET-JRF (2008). She has also Qualified GATE examination, 2008 with 99.65 percentile with All India Rank- 48. Her Ph.D. research work was specifically focused on Protein Purification, Protein Crystallization, Biochemical Characterization of Proteins, Molecular Biology and Macromolecular X-ray Crystallography. She has submitted 21 PDBs in RCSB Protein Data Bank. She has published many international research papers with approx 629 citations. She is a life time member of Indian Crystallographic Association (ICA). She is Reviewer of many reputed journals. She has presented her research papers in various international and national conferences and seminars. She has also won the ‘Best Oral Presentation Award’ in National Seminar on Crystallography (NSC-42), 2013 held at Jawaharlal Nehru University, New Delhi. Her area of research work is Structure based identification and validation of novel lead molecules against drug target proteins from various pathogens.

Qualification

  • Ph.D., All India Institute of Medical Sciences (AIIMS), New Delhi, India (2015)
  • M.Sc. in Industrial Biotechnology, CCS University Campus, Meerut, UP, India
  • B.Sc., in Zoology, Botany and Chemistry, D.D.U. Gorakhpur University Campus

Award and Recognitions

  • Qualified CSIR-JRF National Exam (2008)
  • Qualified CSIR-JRF National Exam (2007)
  • GATE (Graduate Aptitude Test in Engineering) with 99.65 percentile, All India Rank- 48, 2008)
  • Awarded Senior Research Fellow in Oct, 2010
  • Awarded Junior Research Fellow in September 2008
  • Best Oral Presentation Award’, in National Seminar on Crystallography (NSC-42), 2013 held at Jawaharlal Nehru University, New Delhi, India from November 21-23, 2013.

Dr-Rashmi-Prabha-Singh

Research and Scholarly Publication

  • Jha RK,, Khan RJ, Parthiban A, Singh E, Jain M, Amera GM, Singh RP, Ramachandran P, Ramachandran R, Sachithananda V , Muthukumaran J, Singh AK, “Identifying the natural compound catechin from tropical mangrove plants as a potential lead candidate against 3CLpro from SARS-Cov2: an integrated in silico approach”, Journal of Biomolecular Structure & Dynamics, Page 1-20, October 2021 (Indexed in SCI, SCOPUS and WoS)
  • Singh E, Khan RJ, Jha RK, Amera GM, Jain M, Singh RP, Muthukumaran J and Singh AK. “A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods” Journal of Genetic Engineering and Biotechnology , volume 18, issue-1, Page 1-12, Nov 2020 (Indexed in SCOPUS, PubMed Central)
  • Khan RJ, Jha RK, Amera GM, Jain M, Singh E, Singh RP, Muthukumaran J and Singh AK “Identification of promising antiviral drug candidates against non-structural protein 15 (NSP15) from SARS-CoV-2: an in silico assisted drug-repurposing study”. Journal of Biomolecular Structure & Dynamics, Vol-40, Issue-1, Pages 438-448, Sep 2020 (Indexed in SCI, SCOPUS and WoS)
  • Khan RJ, Jha RK, Amera GM, Jain M, Singh E, Pathak A, Singh RP, Muthukumaran J and Singh AK, “Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase”. Journal of Biomolecular Structure & Dynamics, volume 39, Issue-8, Page 2679-2692, Apr 2020 (Indexed in SCI, SCOPUS and WoS)
  • Khan RJ, Jha RK, Amera GM, Jain M, Singh E, Singh RP*, Muthukumaran J, Singh AK, “A Comprehensive in silico Study Towards Understanding the Inhibitory Mechanism of Lactoperoxidase by Dapsone and Propofol”. Science and Current Computer-Aided Drug Design, Vol-17, issue-4, Pages-550-559, Jun 2020 (Indexed in SCI, SCOPUS and Pubmed)
  • Singh, RP., Singh A, Sirohi, H, Singh AK, Kaur P, Sharma S and Singh TP “Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases: structural determination of the lactoperoxidase–methimazole complex at 1.97A resolution, FEBS openbio. Vol 6(7), Page 640-650, 2015 (Indexed in SCI, SCOPUS, WoS and Pubmed)
  • Sinha, M, Singh, RP, Kushwaha, G.S., Iqbal, N., Singh, A., Kaushik, S., Kaur, P., Sharma, S., and Singh, T.P., “Current overview of allergens of plant pathogenesis related protein families” Scientific World Journal, Issue: 543195, 2014 (Indexed in SCOPUS, Pubmed-central)
  • Singh P. K., Ahmad N., Yamini S., Singh RP, Singh A. K., Sharma P, Smith M. L., Sharma S., Singh T. P., “Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase”, Protein Science, Vol-31, Issue-2, Pages 384-395, Feb 2022 (Indexed in SCI, SCOPUS, WoS and Pubmed)
  • Sharma, S, Singh AK, Kaushik S, Sinha, M, Singh, RP., Sharma P., Sirohi H, Kaur P, Singh TP, “Lactoperoxidase: Structural Insights into the Function, Ligand Binding and Inhibition, Int. J. Biochem. Mol. Biol., Vol 4(3), Page 108-12811, 2013. (Indexed in Pubmed)
  • Khan R J, Jha RK., Singh E, Jain M, Amera G., Singh R P, Muthukumaran J, Singh AK “Identification of promising drug candidates against Non-Structural Protein 15 (NSP15) from SARS-CoV-2: an in silico assisted drug-repurposing studies” chemRxiv; 2020. Preprint | ChemRxiv | ID: ppcovidwho-318
  • Khan RJ, Jha R, Amera GM, Jain M, Singh E, Pathak A, Singh RP, Muthukumaran J, Singh A K, “Targeting Novel Coronavirus 2019: A Systematic Drug Repurposing Approach to Identify Promising Inhibitors Against 3C-like Proteinase and 2′-O-Ribose Methyltransferase” chemRxiv; 2020. Preprint | ChemRxiv
  • Singh RP, Singh, A, Sinha M, Kaur P, Bhushan, A, Sharma, S & Singh, TP (2013) “Crystal Structure of the Complex of Goat Lactoperoxidase with an Anti-thyroid Drug Propylthiouracil”,“Crystal Structure of the Complex of Goat Lactoperoxidase with an Anti-thyroid Drug Propylthiouracil” Published as Conference proceedings for 42nd National Seminar on Crystallography.
  • Singh RP, Singh AK, Singh N, Sharma S, Pandey N, Sinha M, Bhushan A., Kaur P, & Singh, TP, “Crystal Structure of Goat lactoperoxidase with an Anti-thyroid Drug Methimazole” Published as Conference proceedings for 41st National Seminar on Crystallograph.
  • Singh RP, Singh AK, Singh N, Sharma S, Pandey N, Sinha M, Bhushan A., Kaur P, & Singh, TP, “Crystal Structure of Goat lactoperoxidase with an Anti-thyroid Drug Methimazole” Published as Conference proceedings for 41st National Seminar on Crystallograph.
  • Singh, RP, Singh, N, Singh AK, Sinha M, Kaur P, Sharma S & Singh TP “Crystal Structure of Goat lactoperoxidase at 2.4 Ǻ” Published as Conference proceedings in 39th National Seminar on Crystallography.
  • Singh, RP, “Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases–structural determination of the lactoperoxidase–methimazole complex at 1.97 Å resolution” Published as Conference proceedings in National Symposium on Therapeutic Advances in Cancer.

Book Chapters

  • Singh, E, Khan RJ, Jha RK, Amera GM, Jain M, Singh RP, Muthukumaran J, Singh AK “Computational Drug Repurposing for the Development of Drugs Against Coronaviruses”, In Silico Modeling of Drugs Against Coronaviruses, Springer Nature, (pp. 135-162), Apr 2021.
  • Singh E, Khan RJ, Jha RK, Amera GM, Jain M, Singh RP, Muthukumaran J, Singh AK “Ligand-Based Approaches for the Development of Drugs Against SARS-CoV-2”, In Silico Modeling of Drugs Against Coronaviruses, Springer Nature, (pp. 117-134), Apr 2021.

Total PDBs Submitted in RCSB Protein Data Bank

S.N. PDB-ID Title
1 6LF7: Crystal structure…hydrogen peroxide at 1.79 Å resolution.
2 5ZGS: Crystal structure … ions in the distal heme cavity
3 5HPW: Mode of binding of antithyroid drug,…and structure determination
4 5FF1: Two way mode of binding of antithyroid drug methimazole…at 1.97 Å resolution
5 4QJQ: Crystal structure… octopamine at 2.1 Å resolution
6 4OEK: Crystal Structure…. Phenylethylamine at 2.47 Å Resolution
7 4MSF: Crystal structure … 3-hydroxymethyl phenol at 1.98 Å resolution
8 4LJJ: Crystal Structure …Acrylonitrile at 1.98 Å Resolution
9 4KSZ Crystal structure … cystiene at 1.98 Å resolution
10 3UBA: Crystal structure … p-hydroxycinnamic acid at 2.6 Å resolution
11 3R5O: Crystal structure …. 4-allyl-2-methoxyphenol at 2.6 Å resolution
12 3SXV: Crystal structure ….amitrole at 2.1 Å resolution
13 3R4X: Crystal structure … pyrazine-2-carboxamide at 2 Å resolution
14 3R55: Crystal structure …Pyrazinamide at 2.1 Å resolution
15 3S4F: Crystal structure …1H-pyrazolo[4,3-c] pyridine at 1.99 Å resolution
16 3RKE: Crystal Structure …4-aminophenyl-4H-imidazole-1-yl methanone at 2.3 Å resolution
17 3QF1: Crystal structure …..at 2.6 Å resolution
18 3R5Q: Crystal structure ….tetrahydrofuran at 2.7 Å resolution
19 3NAK: Crystal structure … hypothiocyanite at 3.3 Å resolution
20 3N8F: Crystal structure …..thiocyanate at 3.2 Å resolution
21 3NIU: Crystal structure …diethylene glycol at 2.9 Å resolution